Supplementary Materials

The PDF file includes:

• Fig. S1. S1R deletion influences a subset of LPS-induced processes without causing global perturbation.
• Fig. S2. Canonical TLR4 signaling in macrophages is unperturbed by S1R deletion.
• Fig. S3. Gating strategy and quantification of immunophenotyping on blood.
• Fig. S4. Gating strategy and quantification of immunophenotyping on peritoneal contents.
• Fig .S5. Gating strategy and quantification of immunophenotyping on spleen and lymph node.
• Fig. S6. S1R controls inflammation in primary fibroblasts.
• Fig. S7. STF affects cytokine production in vitro and in vivo.
• Fig. S8. Anti-inflammatory effect of FLV does not globally suppress cytokine production from human blood.
• Fig. S9. Proposed mechanism of action of S1R during LPS-mediated inflammatory response.

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Other Supplementary Material for this manuscript includes the following:

• Data file S1. Primary data (Excel file).