Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Representation of Mybpc3 mouse models.
  • Fig. S2. In vivo cardiac function and proteomic characterization in Mybpc3 mouse models.
  • Fig. S3. Resting SLs of animal models studied.
  • Fig. S4. The protein and function effects of increasing MyBPC-RNAi titers.
  • Fig. S5. Analysis of Mant-ATP video files.
  • Fig. S6. Mant-ATP assays in cardiac tissues for Myh6764/764 mice with DCM and Myh6764/764 + Mybpc3 RNAi.
  • Table S1. Echocardiographic parameters with MYK-461 administration.
  • Legend for movie S1.
  • Reference (51)

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.avi format). The fluorescent decay during dark ATP chase of Mant-ATP in permeabilized myocardium.