Supplementary Materials

This PDF file includes:

  • Materials and Methods
  • Fig. S1. The effect of TTP399 on GK activity.
  • Fig. S2. TTP399 stimulation of glucose metabolism in isolated rat hepatocytes.
  • Fig. S3. Differential uptake of TTP399 into rat hepatocytes and β cells.
  • Fig. S4. The effect of TTP399 on HbA1c concentrations in diabetic Umeå ob/ob mice.
  • Fig. S5. Liver TG content in diabetic Umeå ob/ob mice after 4 weeks of treatment with TTP399.
  • Fig. S6. Effect of 4 weeks of treatment with TTP399 on body weight and food intake in diabetic Umeå ob/ob mice.
  • Fig. S7. The effect of metformin alone or metformin + TTP399 on blood glucose and insulin levels in Gottingen minipigs.
  • Fig. S8. Metabolic changes at month 6 and over time.
  • Table S1. Area under the plasma glucose concentration-time curve after doses of TTP399 on days 1 and 22 in diabetic Umeå ob/ob mice.
  • Table S2. Plasma insulin concentration before treatment and after 22 days of treatment in diabetic Umeå ob/ob mice.
  • Table S3. Plasma concentrations of TGs and lactic acid during treatment with TTP399 in Gottingen minipigs.
  • Table S4. Hepatic-free glycerol, TGs, and glycogen content after 3 months of treatment with TTP399 (50 mg/kg per day) in Gottingen minipigs.
  • Reference (50)

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