Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Optimization of iRPE differentiation.
  • Fig. S2. Degradation kinetics of PLGA scaffold.
  • Fig. S3. Evaluation of functionally mature iRPE patch.
  • Fig. S4. Assessment of iPSC survival in iRPE cultures.
  • Fig. S5. Safety and efficacy assessment of iRPE patch in rodents.
  • Fig. S6. Optimization of laser-induced RPE injury in pig eyes.
  • Fig. S7. Optimization of subretinal transplantation procedure in pigs.
  • Fig. S8. Analysis of iRPE patch in pig model of laser-induced retinal degeneration.
  • Fig. S9. Comparative efficacy analysis of iRPE patch and iRPE suspension in the pig model.
  • Table S1. Validation of clinical (GMP)–grade iPSC Working Bank derived from CD34+ cells.
  • Table S2. Oncogene exome analysis of iPSC versus donor PBMCs.
  • Table S3. Detailed list of clinical-grade reagents used in iPSC generation and RPE differentiation.
  • Table S4. Summary of body weight change in rats transplanted with iPSC-derived RPE.
  • Table S5. Lactic acid release analysis of in vitro degraded PLGA scaffolds.
  • Legends for files S1 to S3
  • References (53, 54)

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Other Supplementary Material for this manuscript includes the following:

  • File S1 (Microsoft Word format). Images for all replicates described in Figs. 2 to 6 (provided as separate Word file).
  • File S2 (Microsoft Excel format). Raw data for the main figures (provided as separate Excel file).
  • File S3 (Microsoft Excel format). Raw data for the supplementary figures (provided as separate Excel file).