Supplementary Materials

This PDF file includes:

  • Methods
  • Fig. S1. Protection mechanism of the nanoscavenger.
  • Fig. S2. Zeta potential of the native OPH enzyme and nanoscavenger.
  • Fig. S3. Enzyme kinetic measurements of the native OPH and nanoscavenger.
  • Fig. S4. Pharmacokinetic profiles of the native OPH versus nanoscavenger after subcutaneous injections.
  • Fig. S5. Serum anti-OPH antibody titers after subcutaneous administration.
  • Fig. S6. Detection of anti-PCB antibodies in nanoscavenger groups by direct ELISAs.
  • Fig. S7. Detection of anti-PCB antibodies in nanoscavenger groups by SPR sensors.
  • Fig. S8. Histologic examinations of rat organs.
  • Fig. S9. Hemolytic activity tests of the nanoscavengers.
  • Fig. S10. Time-dependent prophylactic efficacy test by subcutaneous administration.
  • Fig. S11. Pharmacokinetic profiles of the native OPH versus nanoscavenger in guinea pigs after intravenous administrations.
  • Fig. S12. DLS of the OPH protein before and after acryloylation.
  • Fig. S13. Standard curves used to convert enzyme activity into concentration.
  • Table S1. Pharmacokinetic parameters after intravenous and subcutaneous injections in rats.
  • Table S2. Pharmacokinetic parameters after intravenous administration in guinea pigs.
  • Table S3. Intoxication score definitions.

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