Supplementary Materials

The PDF file includes:

  • Fig. S1. Patients treated with GAD therapy showed greater improvement in UPDRS ratings but also increases in PDRP.
  • Fig. S2. Metabolic changes over time in GADRP regions.
  • Fig. S3. GAD therapy induces a specific sequence of functional connectivity changes within the GADRP space.
  • Fig. S4. Neither sham surgery nor STN DBS increases degree centrality.
  • Fig. S5. Longitudinal changes in UPDRS motor ratings and expression values for the GADRP, SSRP, and PDRP networks.
  • Table S1. Demographics and clinical measurements.
  • Legend for Table S2
  • Table S3. Changes in degree centrality at GADRP nodes after gene therapy or sham surgery.
  • Legend for Table S4

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Other Supplementary Material for this manuscript includes the following:

  • Table S2 (Microsoft Excel format). Nodal connections within the GADRP space (91 edges) at baseline, 6 months, and 12 months.
  • Table S4 (Microsoft Excel format). Individual patient data: off-state UPDRS motor ratings and expression values (z-scored) for GADRP, SSRP, and PDRP at each time point.