Supplementary Materials

This PDF file includes:

  • Methods
  • Fig. S1. Cell-based potency of inhibitors for IL-5–, TSLP-, and IgE-induced signals.
  • Fig. S2. DPI system.
  • Fig. S3. Co-dose PD model.
  • Fig. S4. IL-13 and Gm-csf PD models.
  • Fig. S5. Dose-response curve of iJak-381 in asthma model.
  • Fig. S6. Complete blood count analysis of iJak-treated animals.
  • Fig. S7. Drug concentrations in AAH model.
  • Table S1. Biochemical selectivity of iJak-381 and oJak-989.

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