Supplementary Materials

This PDF file includes:

  • Fig. S1. IHC with SGLT2 antibody.
  • Fig. S2. Quantification of tracer uptake and protein expression in lung tumors of KPluc mice.
  • Fig. S3. Time course of PET/CT imaging with Me4FDG and FDG in KPluc mice.
  • Fig. S4. Therapeutic trial with canagliflozin in KPluc mice.
  • Fig. S5. Heterogeneity of morphology and glucose transporter expression in PDXs.
  • Table S1. Clinical and pathological features of the 58 LADC samples included in the study.
  • Table S2. Quantification of SGLT2 and GLUT1 expression in low- and high-grade LADC in GEMMs.
  • Table S3. Time-course analysis of SGLT2 and GLUT1 expression in LADC in GEMMs.
  • Table S4. BLI of the mice included in the SGLT2 inhibition trial (survival cohort).
  • Table S5. BLI of the mice included in the SGLT2 inhibition trial (week 8 cohort).

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