Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Age-related decreased bone mass in the radius of patients with WNT1 mutation.
  • Fig. S2. Inactivation of Wnt1 in osteoclasts does not affect bone remodeling.
  • Fig. S3. Histology of the fractures in Runx2-cre;Wnt1fl/fl mice.
  • Fig. S4. Wnt1 is a general bone-anabolic molecule.
  • Fig. S5. Wnt1 induces bone formation in adult mice.
  • Fig. S6. Wnt1 induction protects aging female from bone loss.
  • Fig. S7. Wnt1 expression induces a rapidly increased bone mass in adult mice.
  • Fig. S8. Wnt1 is not directly stimulating osteoblast differentiation.
  • Fig. S9. Wnt1 is not up-regulated during osteoblast differentiation.
  • References (5058)

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Other Supplementary Material for this manuscript includes the following:

  • Table S1. Individual subject-level data (Excel file).