Supplementary Materials

The PDF file includes:

  • Fig. S1. Appearance of HIRD as seen on multimodal imaging during progression.
  • Fig. S2. Refractile drusen with nodules and RPE atrophy in the index case for microanalysis.
  • Fig. S3. SEM of isolated nodules.
  • Fig. S4. Density-dependent SEM of calcific lesions.
  • Fig. S5. Synchrotron microfocus x-ray fluorescence confirms the presence of Ca in large nodules.
  • Fig. S6. TOF-SIMS confirms the presence of HAP within nodules.
  • Fig. S7. Proposed progression stages of calcified structures in AMD.
  • Fig. S8. Two variants of HIRD.
  • Table S1. Composition and appearance of calcified structures in eyes with GA as revealed by multimodal clinical and molecular imaging.
  • Table S2. Table of sample sources.
  • Table S3. D-spacings and I/Imax (%) of candidate calcium phosphate compounds.
  • Legends for datasets S1 and S2
  • Legend for movie S1

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Other Supplementary Material for this manuscript includes the following:

  • Dataset S1 (Microsoft Excel format). Primary data from cohort 1.
  • Dataset S2 (Microsoft Excel format). Primary data from cohort 2.
  • Movie S1 (.mov format). Progression of nodules, spherules, and BrM plaques.