Supplementary Materials

The PDF file includes:

  • Fig. S1. Genetic strategy to generate Piezo2-ChR2 mice.
  • Fig. S2. Mechanically activated currents in nociceptor subtypes of DRG neurons are Piezo2 dependent.
  • Fig. S3. Response to mechanosensory stimulation of the eye (the blink reflex) is normal in Piezo2HoxB8 mice.
  • Fig. S4. Response to innocuous and noxious stimuli in Piezo2HoxB8 mice is not dependent on the sex of the animal.
  • Fig. S5. Aδ- and C-fiber mechanical and thermal thresholds in Piezo2HoxB8 mice.
  • Fig. S6. Capsaicin-induced thermal hyperalgesia is unaffected in Piezo2HoxB8 mice.
  • Fig. S7. Capsaicin-induced mechanical sensitization in Piezo2WT and Piezo2HoxB8 mice.
  • Fig. S8. Capsaicin-induced mechanical allodynia is compromised in Piezo2iAdv mice.
  • Fig. S9. SNI-induced mechanical sensitization in Piezo2WT and Piezo2HoxB8 mice.

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Source data for Figs. 1, 2, and 4 and figs. S1, S3, S5, S6, and S8.