Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Integration of stimulatory response from testing dual-defined mixtures into the original scoring matrix using the HM model.
  • Fig. S2. Response of CSF-infiltrating CD4+ T cells.
  • Fig. S3. New patients and phylogeny of bacterial species sharing GDP-L-fucose synthase peptides.
  • Table S1. Summary of human decapeptides predicted with the biometrical approach, synthesized, and tested for stimulatory capacity.
  • Table S2. GDP-L-fucose synthase, myelin, and CEF peptides.
  • Table S3. Peptides from brain proteins identified by proteomic analysis in brain tissue.
  • Table S4. Negative bootstrap Monte Carlo summary.
  • Table S5. Patient classification and HLA binding.
  • Table S6. Bacteria selected for GDP-L-fucose synthase comparison.
  • Table S7. Sequence identity between human and bacterial GDP-L-fucose synthase peptides.
  • Table S8. Demographic and clinical characteristics of patients with MS and controls without MS.
  • References (6775)

[Download PDF]

Other Supplementary Material for this manuscript includes the following:

  • Table S9 (Microsoft Excel format). Primary data.