Supplementary Materials

The PDF file includes:

  • Fig. S1. Expression of p95HER2 in normal tissues.
  • Fig. S2. Identification and characterization of the epitope recognized by the monoclonal antibody used to generate p95HER2-TCB.
  • Fig. S3. Affinities of the original anti-p95HER2 monoclonal antibody and the anti-p95HER2 TCB.
  • Fig. S4. Effect of anti-p95HER2 and HER2-TCB on cultures of MCF7 p95HER2 cells with or without PBMCs.
  • Fig. S5. Effect of anti-p95HER2 on the activation of CD4+ and CD8+ cells in cocultures of MCF10A cells transfected with HER2 and/or p95HER2 and PBMCs.
  • Fig. S6. Generation of proliferating MCF7 cells expressing p95HER2.
  • Fig. S7. Effects of PBMCs from different donors and of p95HER2-TCB on the growth of MCF7 p95HER2 cells as xenografts.
  • Fig. S8. Effect of p95HER2-TCB on an in vitro model of BBB.
  • Fig. S9. Effect of p95HER2-TCB on parental MCF7 cells and on MCF7 cells transfected with HER2.
  • Fig. S10. Expression of p95HER2 in different PDXs.
  • Fig. S11. Cytokeratin expression and lymphocyte infiltration in PDXs treated with p95HER2-TCB in vivo.

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Other Supplementary Material for this manuscript includes the following:

  • Table S1. Primary data (provided as an Excel file).