Supplementary Materials

The PDF file includes:

  • Methods
  • Fig. S1. Mechanism of ASO-mediated SNP-targeted allele-specific muHTT suppression.
  • Fig. S2. Experimental design.
  • Fig. S3. ASO tolerability.
  • Fig. S4. Comparison of HTT protein at 10 months of age in early- and late-intervention groups.
  • Fig. S5. Body weight.
  • Fig. S6. Accelerating rotarod.
  • Fig. S7. Spontaneous climbing.
  • Fig. S8. Total object investigation time during NOL trial 1.
  • Fig. S9. Supplementary open-field exploration.
  • Fig. S10. Supplementary elevated plus maze exploration.
  • Fig. S11. Cerebellum weight.
  • Table S1. Linear mixed-effect models analysis: HTT protein levels.
  • Table S2. Linear mixed-effect models analysis: Early intervention.
  • Table S3. Linear mixed-effect models analysis: Late intervention.
  • Table S4. ANOVAs with multiple-comparison correction: Early intervention.
  • Table S5. ANOVAs with multiple-comparison correction: Late intervention.

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Other Supplementary Material for this manuscript includes the following: