Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Pathology in LmnaG609G mice.
  • Fig. S2. H&E staining of aortic tissue from young mice and nonaortic tissues from older LmnaG609G/+ mice.
  • Fig. S3. Cell and nuclear morphology in LmnaG609G aortic SMCs.
  • Fig. S4. Nuclear lamin expression in the aorta of WT and LmnaG609G/+ mice.
  • Fig. S5. Analysis of the vascular phenotype in the ascending aorta of LmnaG609G/G609G mice.
  • Fig. S6. Control studies for the lamin-inducible SMC system and the Sm22-Cre–dependent activation of KASH2 expression in the aorta.
  • Table S1. Antibodies used for Western blotting and immunohistochemistry.
  • Table S2. Quantitative RT-PCR primers.
  • Legend for table S3
  • Reference (69)

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Other Supplementary Material for this manuscript includes the following:

  • Table S3 (Microsoft Excel format). Individual subject-level data.