Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. PD-1 up-regulation in fibrotic lung disease.
  • Fig. S2. CD4+ T cells secreting LAP/TGF-β1.
  • Fig. S3. Increased Tregs in sarcoidosis.
  • Fig. S4. Increased IL-6 expression in sarcoidosis CD4+ T cells after TCR stimulation.
  • Fig. S5. TGF-β1 secretion by CD4+ T cell subsets.
  • Fig. S6. Increased intracellular TGF-β1 expression by CD4+IL-17A+ T cells.
  • Fig. S7. Collagen-1 production by fibroblasts cocultured with sarcoidosis CD4+ T cells with high and low PD-1 baseline expression.
  • Fig. S8. Fibrosis markers in cocultured supernatants.
  • Fig. S9. CD4+ T cells secreting LAP/TGF-β1.
  • Fig. S10. STATTIC specificity in CD4+ T cells.
  • Fig. S11. Reduced RORC expression after PD-1 blockade.
  • Fig. S12. IL-12 expression in IPF patients in the discovery cohort.
  • Fig. S13. Reduced IL-23R expression in PD-1 null bleomycin-treated mice.
  • Table S1. HLF and sarcoidosis PD-1+CD4+ T cell coculture demonstrates increased collagen-1 synthesis.

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Other Supplementary Material for this manuscript includes the following:

  • Table S2 (Microsoft Excel format). Primary data.