Supplementary Materials

The PDF file includes:

  • Fig. S1. Patients show a missense mutation in the catalytic domain of SIK3.
  • Fig. S2. Quantification of protein amounts of Western blots in Fig. 3A.
  • Fig. S3. Serum and insulin treatment in control and patient cells.
  • Fig. S4. Quantification of protein amounts of Western blots in Fig. 3 (D and E).
  • Fig. S5. Quantification of protein amounts of Western blots in Fig. 5.
  • Fig. S6. PTHrP treatment in primary chondrocytes.
  • Fig. S7. Model of action of SIK3.
  • Table S1. Clinical findings of affected individuals with a mutation in SIK3.

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Other Supplementary Material for this manuscript includes the following:

  • Table S2 (Microsoft Excel format). Individual subject-level data.