Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Loss of ANP32A increases the severity of osteoarthritis in the collagenase- and papain-induced mouse models.
  • Fig. S2. Expression of molecular markers associated with healthy chondrocytes in the presence or absence of ANP32A.
  • Fig. S3. Transcriptome network analysis of articular cartilage of Anp32a-deficient mice.
  • Fig. S4. Compensatory regulation of antioxidant systems in the articular cartilage of Anp32a-deficient mice.
  • Fig. S5. Immunohistochemistry of COLX in the growth plates of 16-week-old male Anp32a−/− compared to WT mice.
  • Fig. S6. Calbindin immunostaining of cerebellar Purkinje cells of 16-week-old male WT and Anp32a-deficient mice.
  • Fig. S7. Late-stage antioxidant intervention in Anp32a-deficient mice ameliorates ataxia-related defects.
  • Fig. S8. Model for the role of ANP32A on oxidative stress.
  • Table S1. Patient characteristics.
  • Table S2. Top ranked genes of transcriptome network of articular cartilage of 8-week-old Anp32a-deficient male mice compared to WT mice.
  • Table S3. Gene expression of main antioxidants in transcriptome network of articular cartilage of 8-week-old male Anp32a-deficient mice compared to WT mice.
  • Table S4. Gait parameters of early-stage antioxidant intervention with NAC in Anp32a-deficient mice.
  • Table S5. Animal experiments: Overview, setup, and analysis details.
  • Table S6. Primers used in qPCR analysis.
  • References (7278)

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