Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Chemical synthesis scheme for compounds 1 to 6.
  • Fig. S2. AT-121 plasma and brain concentrations after a single subcutaneous administration of 3 mg/kg to male Sprague-Dawley rats.
  • Fig. S3. In vitro plasma stability assessment of AT-121 in nonhuman primate plasma.
  • Fig. S4. Effects of systemic administration of AT-121 on physiologic functions of freely moving nonhuman primates implanted with telemetric probes.
  • Table S1. Brain sample records for AT-121 brain penetration after subcutaneous administration of 3 mg/kg to male Sprague-Dawley rats.
  • Table S2. Pharmacokinetic parameters (plasma and brain) for AT-121 after subcutaneous administration in male Sprague-Dawley rats.
  • Table S3. Plasma stability assessment of AT-121 in nonhuman primate plasma.
  • Table S4. Baseline values for the nonhuman primate tail-withdrawal assay that are normalized across different dosing conditions.
  • References (74, 75)

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Other Supplementary Material for this manuscript includes the following:

  • Table S5 (Microsoft Excel format). Raw data.