Supplementary Materials

The PDF file includes:

  • Fig. S1. Changes in nuclear lamins with ventilation.
  • Fig. S2. Lamin-A and Lamin-B in airway epithelium and lung endothelium in patients.
  • Fig. S3. Changes in lamin content and nuclear compliance in epithelial cells and fibroblasts.
  • Fig. S4. Stretch-induced lung injury in Lamin-A–deficient mice (LmnaLCS/LCS).
  • Fig. S5. Differences in the inflammatory response to ventilation between genotypes.
  • Fig. S6. Prelamin-A and Lamin-B abundance in Zmpste24−/− mice subjected to mechanical ventilation.
  • Fig. S7. Prelamin-A and Lamin-A staining after ventilation.
  • Fig. S8. Endotoxin-induced lung injury in wild-type and Zmpste24−/− mice.
  • Fig. S9. Principal components analysis of the microarray data.
  • Fig. S10. Differential mechanosensitive gene expression in wild-type and Zmpste24−/− mice subjected to mechanical ventilation.
  • Fig. S11. Differential expression of genes involved in apoptosis.
  • Fig. S12. Apoptosis after LPS injection in wild-type and Zmpste24−/− mice.
  • Fig. S13. Effects of HIV protease inhibitors in LmnaLCS/LCS mice.
  • Fig. S14. Effects of HIV protease inhibitors in Zmpste24−/− mice.
  • Fig. S15. Effects of lopinavir/ritonavir on the repair phase after VILI.
  • Fig. S16. Genetic and pharmacological blockade of the mechanical response to mechanical ventilation.
  • Fig. S17. Respiratory mechanics at baseline.
  • Table S1. Patients’ characteristics.
  • Table S2. Statistical power of nonsignificant comparisons.

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Other Supplementary Material for this manuscript includes the following:

  • Table S3 (Microsoft Excel format). Raw data.