Supplementary Materials

The PDF file includes:

• Fig. S1. Senescence markers in human acute liver disease.
• Fig. S2. Senescence in the acute CCl₄ model.
• Fig. S3. Senescence in the acute acetaminophen model.
• Fig. S4. Senescence in acute dietary models of liver injury.
• Fig. S5. Hepatocyte Mdm2 deletion model.
• Fig. S6. Non–cell-autonomous senescence marker induction.
• Fig. S7. Hepatocyte TGFβ pathway activation model.
• Fig. S8. Hepatocyte TGFβ pathway promotes hepatic TGFβ ligand production.
• Fig. S9. TGFβ pathway activity in the acetaminophen model.
• Fig. S10. Serial sections of the TGFβ pathway and senescent hepatocytes.
• Fig. S11. Macrophage recruitment, TGFβ secretion, and induced senescence.
• Fig. S12. TGFβR1 inhibition in acute and chronic CCl₄ models.
• Fig. S13. Genetic deletion of hepatocyte TGFβR1 in the acetaminophen model.
• Fig. S14. Therapeutic TGFβR1 inhibition in the acetaminophen model.
• Fig. S15. Schematic representation of paracrine-induced senescence in acute liver injury.
• Fig. S16. Ductular reaction responses in murine models and human disease.
• Table S2. RNA-seq gene: Hallmarks.
• Table S3. RNA-seq GSEA: Selected ranked hallmarks and OIS signature.

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Other Supplementary Material for this manuscript includes the following:

• Table S1 (Microsoft Excel format). Source data for Fig. 2.
• Table S4 (Microsoft Excel format). Source data for Fig. 3.
• Table S5 (Microsoft Excel format). Source data for Fig. 4.
• Table S6 (Microsoft Excel format). Source data for Fig. 5.
• Table S7 (Microsoft Excel format). Source data for Fig. 6.

[Download Tables S1, S4 to S7]