Supplementary Materials
The PDF file includes:
- Fig. S1. Senescence markers in human acute liver disease.
- Fig. S2. Senescence in the acute CCl4 model.
- Fig. S3. Senescence in the acute acetaminophen model.
- Fig. S4. Senescence in acute dietary models of liver injury.
- Fig. S5. Hepatocyte Mdm2 deletion model.
- Fig. S6. Non–cell-autonomous senescence marker induction.
- Fig. S7. Hepatocyte TGFβ pathway activation model.
- Fig. S8. Hepatocyte TGFβ pathway promotes hepatic TGFβ ligand production.
- Fig. S9. TGFβ pathway activity in the acetaminophen model.
- Fig. S10. Serial sections of the TGFβ pathway and senescent hepatocytes.
- Fig. S11. Macrophage recruitment, TGFβ secretion, and induced senescence.
- Fig. S12. TGFβR1 inhibition in acute and chronic CCl4 models.
- Fig. S13. Genetic deletion of hepatocyte TGFβR1 in the acetaminophen model.
- Fig. S14. Therapeutic TGFβR1 inhibition in the acetaminophen model.
- Fig. S15. Schematic representation of paracrine-induced senescence in acute liver injury.
- Fig. S16. Ductular reaction responses in murine models and human disease.
- Table S2. RNA-seq gene: Hallmarks.
- Table S3. RNA-seq GSEA: Selected ranked hallmarks and OIS signature.
Other Supplementary Material for this manuscript includes the following:
- Table S1 (Microsoft Excel format). Source data for Fig. 2.
- Table S4 (Microsoft Excel format). Source data for Fig. 3.
- Table S5 (Microsoft Excel format). Source data for Fig. 4.
- Table S6 (Microsoft Excel format). Source data for Fig. 5.
- Table S7 (Microsoft Excel format). Source data for Fig. 6.