Supplementary Materials

The PDF file includes:

  • Materials and methods
  • Fig. S1. Optimization of tissue-engineered ossicle generation.
  • Fig. S2. Longitudinal characterization of mTEBC maturation.
  • Fig. S3. Functional analysis of bone marrow in TEBC and bone marrow transplantation experiments.
  • Fig. S4. 3D organization and functionality of blood vessels in mTEBC.
  • Fig. S5. Topology and position of solid PC3 tumors in mTEBC.
  • Fig. S6. C4-2B and MDA-MB-231 tumor cell administration and monitoring by μCT, x-ray, histology, and iMPM.
  • Fig. S7. Analysis of the bone morphologies ex vivo.
  • Fig. S8. Imaging analysis of PC3-mediated osteolytic lesions by iMPM.
  • Fig. S9. Distribution of osteoclasts and Cat K+ cells within mTEBC.
  • Fig. S10. PIV analysis of response to zoledronate therapy monitored by iMPM.
  • Legends for movies S1 to S5
  • References (5559)

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.avi format). 3D reconstruction of PC3 lesion in mTEBC.
  • Movie S2 (.mov format). 3D reconstruction of a PC3 osteolytic lesion in mTEBC.
  • Movie S3 (.avi format). Kinetics of a Cat K+ cell.
  • Movie S4 (.avi format). Kinetics of Cat K+ cell overview.
  • Movie S5 (.avi format). Kinetics of a Cat K+ cell after ZA treatment.