Supplementary Materials

The PDF file includes:

  • Fig. S1. Controls used in the siRNA screen.
  • Fig. S2. Controls for SMAD2/3 expression and carboplatin responses in HEK293 cells in vitro.
  • Fig. S3. Positive controls for SMAD2/3 expression in vitro.
  • Fig. S4. Responses of lung adenocarcinoma cell lines to chemotherapy agents with TGFβ signaling pathway activation in vitro.
  • Fig. S5. Evaluation of activin A and GDF8/11 expression in lung adenocarcinoma.
  • Fig. S6. Effect of SB-505124 on the platinum response in vivo.
  • Fig. S7. Effect of FST on the platinum response in vivo.
  • Fig. S8. Mouse weights in xenograft/allograft experiments.
  • Fig. S9. Examples of full-length Western blots with image cropping.
  • Table S2. High-confidence hits targetable with existing small or large molecules.
  • Table S3. Characteristics of the patient cohort used to generate immunohistochemical data.

[Download PDF]

Other Supplementary Material for this manuscript includes the following:

  • Table S1. Complete data set from the primary siRNA screen (provided as an Excel file).
  • Table S4. Details of reagents used (provided as an Excel file).

[Download Tables S1 and S4]