Supplementary Materials

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Active LRRK2 is detected by proximity ligation in microglia in control brains and is increased in iPD and in rotenone-treated rats.
  • Fig. S2. Time course of in vivo rotenone-induced LRRK2 activation as assessed by pSer1292-LRRK2 proximity ligation signal.
  • Fig. S3. LRRK2 is activated by oligomeric but not monomeric α-synuclein.
  • Fig. S4. Rotenone-induced accumulation of pSer129-α-synuclein is LRRK2-dependent.
  • Fig. S5. Activation of LRRK2 kinase activity in iPD and its downstream consequences.
  • References (3638)

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