Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. DR expression, engineering of DRL-resistant cancer cells with Rl-ST, and in vitro coculture efficacy.
  • Fig. S2. Screening and identification of CRISPR-induced DR-KO.
  • Fig. S3. Engineering of cell lines for in vivo BLI and ST expression from DR4/5 KO cell lines.
  • Fig. S4. ELISA quantification of secreted TRAIL from CRISPR-engineered therapeutic cancer cell lines.
  • Fig. S5. Concept of autologous cancer cell–based self-targeting strategies and possible role of GCV-activated HSV-TK suicide system in case of DRL nonresponsive tumor recurrence.
  • References (7078)

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Other Supplementary Material for this manuscript includes the following:

  • Table S1. Establishment of sGBMnRec-FmC recurrent cell line via in vivo TMZ treatment of sGBMn-FmC (provided as an Excel file).
  • Table S2. Establishment of sGBMiRec-FmC recurrent cell line via in vivo TMZ treatment of sGBMi-FmC (provided as an Excel file).

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