Supplementary Materials

  • This PDF file includes:
  • Materials and Methods
  • Fig. S1. Lower claudin-5 protein in brains of DM rats.
  • Fig. S2. No leakage of a large dextran tracer indicates normal vascular integrity in 5-week-old DM rats.
  • Fig. S3. No difference in astrocytes or pericytes.
  • Fig. S4. Increased number of OPCs due to increased proliferation in DM rats and diseased human brains.
  • Fig. S5. Brains of young, prehypertensive DM rats and presymptomatic humans show increased numbers of microglia/macrophages.
  • Fig. S6. More HSP90α is secreted by BMECs isolated from DM rats.
  • Fig. S7. Addition of rHSP90α or use of blocking antibodies to HSP90α has no effect on OPC proliferation.
  • Fig. S8. CM from human ECs treated with ATP11B siRNA reduces OPC maturation.
  • Fig. S9. Human cerebral ECs from the HBEC5i and hCMEC/d3 lines do not express endothelial markers.
  • Fig. S10. SNPs within ATP11B are associated with WMH in the CHARGE consortium data.
  • Fig. S11. Summary of findings illustrating the central role of endothelial dysfunction in SVD pathology.
  • Table S1. Summary of human SVD and control postmortem data and pathological characteristics.
  • Table S2. Summary of treatment groups in drug study.
  • References (7177)

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