Supplementary Materials

Supplementary Material for:

Tissue engineering toward temporomandibular joint disc regeneration

Natalia Vapniarsky, Le W. Huwe, Boaz Arzi, Meghan K. Houghton, Mark E. Wong, James W. Wilson, David C. Hatcher, Jerry C. Hu, Kyriacos A. Athanasiou*

*Corresponding author. Email: athens{at}uci.edu

Published 20 June 2018, Sci. Transl. Med. 10, eaaq1802 (2018)
DOI: 10.1126/scitranslmed.aaq1802

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Tissue-engineered implants’ tensile and compressive properties at various time points in vitro (t = 0 and 5 weeks) and in vivo (t = 8 weeks).
  • Fig. S2. Method and outcome of the preliminary in vivo experiment exploring disc perforation defect and suture fixation of tissue-engineered implants (n = 3 shown).
  • Fig. S3. Representative external appearances of implantation sites 8 weeks after surgery in tissue-engineered implant–treated groups and empty controls, respectively (n = 6).
  • Fig. S4. The mandibular head articulating surfaces’ gross appearances in tissue-engineered implant–treated groups and untreated controls 8 weeks after implantation (n = 6).
  • Fig. S5. Low-magnification histology (H&E) of the mandibular heads of tissue-engineered implant–treated groups and untreated controls 8 weeks after implantation (n = 6).
  • Fig. S6. Schematic diagram showing specimen preparation for mechanical and histological assessments of the tissue-engineered implant–treated TMJ discs and of the discs with untreated defects.
  • Fig. S7. The intralaminar fenestration technique’s ex vivo feasibility validation (n = 3).
  • References (6265)

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Other Supplementary Material for this manuscript includes the following: