Supplementary Materials

Supplementary Material for:

Acute and chronic neurological consequences of early-life Zika virus infection in mice

Isis Nem de Oliveira Souza, Paula S. Frost, Julia V. França, Jéssica B. Nascimento-Viana, Rômulo L. S. Neris, Leandro Freitas, Daniel J. L. L. Pinheiro, Clara O. Nogueira, Gilda Neves, Leila Chimelli, Fernanda G. De Felice, Ésper A. Cavalheiro, Sergio T. Ferreira, Iranaia Assunção-Miranda,* Claudia P. Figueiredo,* Andrea T. Da Poian,* Julia R. Clarke*

*Corresponding author. Email: juliaclarke{at}pharma.ufrj.br (J.R.C.); iranaiamiranda{at}micro.ufrj.br (I.A.-M.); claufig{at}gmail.com (C.P.F.); dapoian{at}bioqmed.ufrj.br (A.T.D.P.)

Published 6 June 2018, Sci. Transl. Med. 10, eaar2749 (2018)
DOI: 10.1126/scitranslmed.aar2749

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Late viral brain replication and seizure evaluation in UV-inactivated ZIKV-injected mice.
  • Fig. S2. Electrode implantation and electrographic recordings from mock- and UV-inactivated ZIKV-injected mice.
  • Fig. S3. DENV does not induce seizures or long-term behavioral impairment in Swiss mice.
  • Fig. S4. Neonatal ZIKV infection had no effect on the development of reflexes in newborn mice.
  • Fig. S5. Neonatal ZIKV infection induces motor and cognitive dysfunction in female mice.
  • Fig. S6. Neonatal ZIKV infection does not affect cellular proliferation in the hippocampus.
  • Table S1. Seizure analysis in ZIKV-injected mice.
  • References (4551)

[Download PDF]

Other Supplementary Material for this manuscript includes the following:

  • Table S2. Raw data of main figures (Excel file provided separately).
  • Table S3. Raw data of supplementary figures (Excel file provided separately).

[Download Tables S2 and S3]