Supplementary Materials

Supplementary Material for:

Pannexin-1 channels contribute to seizure generation in human epileptic brain tissue and in a mouse model of epilepsy

Elena Dossi, Thomas Blauwblomme, Julien Moulard, Oana Chever, Flora Vasile, Eleonore Guinard, Marc Le Bert, Isabelle Couillin, Johan Pallud, Laurent Capelle, Gilles Huberfeld, Nathalie Rouach*

*Corresponding author. Email: nathalie.rouach{at}college-de-france.fr

Published 30 May 2018, Sci. Transl. Med. 10, eaar3796 (2018)
DOI: 10.1126/scitranslmed.aar3796

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Absence of spontaneous IIDs and induced IDs in control tissues from epileptic patients.
  • Fig. S2. Unaltered ID induction and maintenance in the presence of scPanx.
  • Fig. S3. Generation of Panx1−/− mice.
  • Fig. S4. Epileptic activity recorded in a patient cortical area in vivo and ex vivo after surgical resection.
  • Fig. S5. MEA recordings of epileptic activities in human cortical slices.
  • Table S1. Clinical, imaging, and neuropathological characteristics of patients involved in the study.
  • Table S2. Properties of IIDs and IDs recorded from the different types of epileptic tissues.

[Download PDF]

Other Supplementary Material for this manuscript includes the following:

  • Table S3. Raw data (provided as an Excel file).