Supplementary Materials

Supplementary Material for:

Adult rat myelin enhances axonal outgrowth from neural stem cells

Gunnar H. D. Poplawski, Richard Lie, Matt Hunt, Hiromi Kumamaru, Riki Kawaguchi, Paul Lu, Michael K. E. Schäfer, Grace Woodruff, Jacob Robinson, Philip Canete, Jennifer N. Dulin, Cedric G. Geoffroy, Lutz Menzel, Binhai Zheng, Giovanni Coppola, Mark H. Tuszynski*

*Corresponding author. Email: mtuszynski{at}ucsd.edu

Published 23 May 2018, Sci. Transl. Med. 10, eaal2563 (2018)
DOI: 10.1126/scitranslmed.aal2563

This PDF file includes:

  • Fig. S1. NPC-derived axon growth is stimulated by a myelin substrate in vitro.
  • Fig. S2. Mouse E12 spinal cord–derived NPC neurite growth is stimulated by a myelin substrate in vitro.
  • Fig. S3. Axon (Tau1) growth is stimulated by a myelin substrate in vitro.
  • Fig. S4. E14 rat spinal cord–derived NPCs lose their ability to be stimulated by myelin upon in vitro maturation.
  • Fig. S5. Growth-dependent mechanisms involving pERK.
  • Fig. S6. Quality measures of RNA-seq.
  • Fig. S7. qPCR verification of RNA-seq.
  • Fig. S8. Overexpression of Negr1 in mature spinal cord–derived NPCs increases neurite growth on a myelin substrate in vitro.
  • Table S1. Individual level data for experiments with n < 20.

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