Supplementary Materials

Supplementary Material for:

Alloreactive fetal T cells promote uterine contractility in preterm labor via IFN-γ and TNF-α

Michela Frascoli, Lacy Coniglio, Russell Witt, Cerine Jeanty, Shannon Fleck-Derderian, Dana E. Myers, Tzong-Hae Lee, Sheila Keating, Michael P. Busch, Philip J. Norris, Qizhi Tang, Giovanna Cruz, Lisa F. Barcellos, Nardhy Gomez-Lopez, Roberto Romero, Tippi C. MacKenzie*

*Corresponding author. Email: tippi.mackenzie{at}

Published 25 April 2018, Sci. Transl. Med. 10, eaan2263 (2018)
DOI: 10.1126/scitranslmed.aan2263

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Treg phenotype in patients with PTL.
  • Fig. S2. Intact ability of maternal T cells to proliferate upon TCR stimulation.
  • Fig. S3. Increased myometrial cell contractility in response to fetal T cells from patients with PTL.
  • Fig. S4. Phenotypic characterization of activated and nonactivated mouse T cells.
  • Fig. S5. Schematic comparison of the fetal immune system between term and PTL.
  • Fig. S6. Equivalent expression of costimulatory molecules on maternal and fetal sBc.
  • Table S1. Demographics of control (n = 89) and PTL (n = 70) patients.
  • Table S2. Clinical characteristics of PTL patients (n = 70).
  • Table S3. Fetal plasma cytokines (control, n = 28; PTL, n = 18).
  • Table S4. Maternal plasma cytokines (control, n = 28; PTL, n = 15).
  • Table S5. HLA mismatch of control (n = 13) and PTL (n = 16) patients.

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Other Supplementary Material for this manuscript includes the following:

  • Table S6 (Microsoft Excel format). Primary data.