Supplementary Materials

Supplementary Material for:

Pharmacokinetics of rifapentine and rifampin in a rabbit model of tuberculosis and correlation with clinical trial data

Dalin Rifat, Brendan Prideaux, Radojka M. Savic, Michael E. Urbanowski, Teresa L. Parsons, Brian Luna, Mark A. Marzinke, Alvaro A. Ordonez, Vincent P. DeMarco, Sanjay K. Jain, Veronique Dartois, William R. Bishai, Kelly E. Dooley*

*Corresponding author. Email: kdooley1{at}jhmi.edu

Published 4 April 2018, Sci. Transl. Med. 10, eaai7786 (2018)
DOI: 10.1126/scitranslmed.aai7786

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Concentration-time curve in plasma and lung tissue after a single dose of 30 mg/kg rifapentine administered to healthy rabbits.
  • Fig. S2. Concentration-time curve for rifampin and rifapentine in plasma and lung lesions after a single drug dose in rabbits with pulmonary cavitary TB.
  • Fig. S3. Concentration-time curve for rifampin or rifapentine in plasma after multiple doses in rabbits with cavitary TB sacrificed 2 or 12 hours after the final drug dose.
  • Fig. S4. Absolute drug concentrations of rifampin or rifapentine in different compartments of lung lesions after single or multiple doses in rabbits with pulmonary cavitary TB.
  • Fig. S5. PK model describing tissue penetration of rifampin and rifapentine.
  • Table S1. PK parameters of rifampin and rifapentine in plasma and in lung lesions after a single drug dose.

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