Supplementary Materials

Supplementary Material for:

Ablation of the stress protease OMA1 protects against heart failure in mice

Rebeca Acin-Perez,* Ana Victoria Lechuga-Vieco, Maria del Mar Muñoz, Rocío Nieto-Arellano, Carlos Torroja, Fátima Sánchez-Cabo, Concepción Jiménez, Andrés González-Guerra, Isabel Carrascoso, Cristiane Benincá, Pedro M. Quiros, Carlos López-Otín, José María Castellano, Jesús Ruíz-Cabello, Luis Jesús Jiménez-Borreguero, José Antonio Enríquez*

*Corresponding author. Email: jaenriquez{at}cnic.es (J.A.E.); rebeca.acin{at}cnic.es (R.A.-P.)

Published 28 March 2018, Sci. Transl. Med. 10, eaan4935 (2018)
DOI: 10.1126/scitranslmed.aan4935

This PDF file includes:

  • Fig. S1. Histological analysis of brain, liver, and kidney sections upon work overload.
  • Fig. S2. Short chronic ISO administration (7 days) promotes ROS increase and mitochondrial crista remodeling.
  • Fig. S3. Modulation of mitochondrial remodeling and calcium homeostasis.
  • Fig. S4. Analysis of heart performance upon pressure overload.
  • Fig. S5. Assessment of cardiac function after HFD administration.

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Number of samples used in the experiments shown in Figs. 1 to 7.