Supplementary Materials

Supplementary Material for:

Fast direct neuronal signaling via the IL-4 receptor as therapeutic target in neuroinflammation

Christina F. Vogelaar, Shibajee Mandal, Steffen Lerch, Katharina Birkner, Jerome Birkenstock, Ulrike Bühler, Andrea Schnatz, Cedric S. Raine, Stefan Bittner, Johannes Vogt, Jonathan Kipnis, Robert Nitsch, Frauke Zipp*

*Corresponding author. Email: frauke.zipp{at}unimedizin-mainz.de

Published 28 February 2018, Sci. Transl. Med. 10, eaao2304 (2018)
DOI: 10.1126/scitranslmed.aao2304

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Dose-response curve.
  • Fig. S2. IL-4R expression in IL-4R fl/fl CamKIIα Cre mice.
  • Fig. S3. Histological analysis of the IL-4R fl/fl CamKIIα Cre+ and Cre spinal cord.
  • Fig. S4. IL-4R expression in spinal cord axons.
  • Fig. S5. Quantification of locomotor parameters using the CatWalk system.
  • Fig. S6. Early IL-4 treatment of C57Bl6 MOG EAE.
  • Fig. S7. Axonal growth on inhibitory Nogo-A.
  • Fig. S8. IL-4R subtypes and absence of IL-13 effect.
  • Fig. S9. IL-4R signaling pathway in neurons.
  • Fig. S10. FACS analysis and histology after nasal IL-4.
  • Legends for movies S1 to S3
  • References (5359)

[Download PDF]

Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Primary data.
  • Movie S1 (.avi format). Representative CatWalk run for a healthy mouse (pre-induction, d0).
  • Movie S2 (.avi format). Representative CatWalk run for a healthy mouse (pre-induction, d0).
  • Movie S3 (.avi format). Representative CatWalk run for a healthy mouse (pre-induction, d0).

Table S1

[Download Movies S1 to S3]