Supplementary Materials

Supplementary Material for:

An off-target effect of BX795 blocks herpes simplex virus type 1 infection of the eye

Dinesh Jaishankar, Abraam M. Yakoub, Tejabhiram Yadavalli, Alex Agelidis, Neel Thakkar, Satvik Hadigal, Joshua Ames, Deepak Shukla*

*Corresponding author. Email: dshukla{at}

Published 14 February 2018, Sci. Transl. Med. 10, eaan5861 (2018)
DOI: 10.1126/scitranslmed.aan5861

This PDF file includes:

  • Materials and Methods
  • Fig. S1. BX795 blocks virus secretion and shows antiviral activity in other cell types.
  • Fig. S2. BX795 shows higher potency compared to existing antivirals.
  • Fig. S3. Therapeutic concentration of BX795 is nontoxic in HCE cells.
  • Fig. S4. BX795 does not mediate antiviral activity through TBK1.
  • Fig. S5. Antiviral activity of BX795 in the in vivo and ex vivo models of corneal infection.
  • Fig. S6. Uncropped blots for figures.
  • Fig. S7. Uncropped blots for supplementary figures.
  • References (62–68)

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Primary data.