Supplementary Materials

Supplementary Material for:

FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis

Tokio Matsuzaki, Oscar Alvarez-Garcia, Sho Mokuda, Keita Nagira, Merissa Olmer, Ramya Gamini, Kohei Miyata, Yukio Akasaki, Andrew I. Su, Hiroshi Asahara, Martin K. Lotz*

*Corresponding author. Email: mlotz{at}

Published 14 February 2018, Sci. Transl. Med. 10, eaan0746 (2018)
DOI: 10.1126/scitranslmed.aan0746

This PDF file includes:

  • Fig. S1. Skeletal and growth plate changes in Col2Cre-FoxO KO mice.
  • Fig. S2. Real-time PCR of cartilage from 1- and 2-month-old Col2Cre KO mice.
  • Fig. S3. Histological features in the growth plate in 4- and 6-month-old Col2Cre KO mice.
  • Fig. S4. Real-time PCR of cartilage from AcanCreERT-TKO mice.
  • Fig. S5. Synovial and bone histological scores in AcanCreERT-TKO mice.
  • Table S1. Numbers of mice used for each experiment.
  • Table S2. TaqMan probes used for real-time PCR analysis.

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Other Supplementary Material for this manuscript includes the following:

  • Table S3 (Microsoft Excel format). Subjective-level data.