Supplementary Materials

Supplementary Material for:

Targeting mitochondrial responses to intra-articular fracture to prevent posttraumatic osteoarthritis

Mitchell C. Coleman,* Jessica E. Goetz, Marc J. Brouillette, Dongrim Seol, Michael C. Willey, Emily B. Petersen, Hope D. Anderson, Nathan R. Hendrickson, Jocelyn Compton, Behnoush Khorsand, Angie S. Morris, Aliasger K. Salem, Douglas C. Fredericks, Todd O. McKinley, James A. Martin

*Corresponding author. Email: mitchell-coleman{at}

Published 7 February 2018, Sci. Transl. Med. 10, eaan5372 (2018)
DOI: 10.1126/scitranslmed.aan5372

This PDF file includes:

  • Fig. S1. Amobarbital does not inhibit complexes II, III, and IV of the ETC.
  • Fig. S2. Standard blood chemistry panel result 6 and 12 months after fracture.
  • Fig. S3. PTOA is macroscopically apparent by 6 months without treatment.
  • Fig. S4. Sustained release of NAC does not augment NAC efficacy at 6 months.
  • Fig. S5. Amobarbital and NAC improve pain scores at 6 months but not during recovery.
  • Fig. S6. Histology shows highly variable subchondral bone thickness 12 months after IAF.
  • Fig. S7. Intra-articular rapamycin reverses mitochondrial dysfunction after meniscal injury.
  • Fig. S8. Contributions of mitochondrial responses following IAF to PTOA.

[Download PDF]