Supplementary Materials

Supplementary Material for:

Sensory deprivation after focal ischemia in mice accelerates brain remapping and improves functional recovery through Arc-dependent synaptic plasticity

Andrew W. Kraft, Adam Q. Bauer, Joseph P. Culver, Jin-Moo Lee*

*Corresponding author. Email: leejm{at}wustl.edu

Published 31 January 2018, Sci. Transl. Med. 10, eaag1328 (2018)
DOI: 10.1126/scitranslmed.aag1328

This PDF file includes:

  • Fig. S1. Arc gene deletion does not affect infarct volume.
  • Fig. S2. Arc gene deletion does not alter perilesional reactive astrocytosis.
  • Fig. S3. Full-range activation heat maps mirror thresholded activation maps.
  • Fig. S4. Mean oxy-Hb intensity maps are similar to activation heat maps.
  • Fig. S5. P value maps show accelerated remapping into the whisker barrel cortex in sensory-deprived mice.
  • Fig. S6. Baseline right S1FP activation intensity is similar in all groups.
  • Fig. S7. Baseline forepaw activation is similar in location for all groups of mice.
  • Fig. S8. Left S1FP and right hindpaw (S1HP) activations remain intact before and after injury.
  • Fig. S9. Left S1FP activation remains intact throughout injury and recovery.
  • Fig. S10. Right S1FP remaps after focal ischemia, but left S1FP remains stable throughout the time course.
  • Fig. S11. Whisker deprivation does not affect limb use symmetry.
  • Fig. S12. Dendritic spine density is lower in perilesional cortex compared to distant cortical regions.
  • Fig. S13. Right S1FP maps remain stable after whisker regrowth.
  • Fig. S14. Right S1WB area is smaller in WT-Depriv compared to WT-Control groups.
  • Fig. S15. Oxy-Hb contrast demonstrates the greatest signal-to-noise ratio of all spectral components.

[Download PDF]