Supplementary Materials

Supplementary Material for:

Miniaturized neural system for chronic, local intracerebral drug delivery

Canan Dagdeviren, Khalil B. Ramadi, Pauline Joe, Kevin Spencer, Helen N. Schwerdt, Hideki Shimazu, Sebastien Delcasso, Ken-ichi Amemori, Carlos Nunez-Lopez, Ann M. Graybiel, Michael J. Cima,* Robert Langer*

*Corresponding author. Email: mjcima{at}mit.edu (M.J.C.); rlanger{at}mit.edu (R.L.)

Published 24 January 2018, Sci. Transl. Med. 10, eaan2742 (2018)
DOI: 10.1126/scitranslmed.aan2742

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Schematic illustration of fabricating a MiNDS.
  • Fig. S2. Schematic illustration and SEM image of Hamilton needle.
  • Fig. S3. Photographs of the steps for polishing and cleaning the tip of a BS channel.
  • Fig. S4. SEM images of the components of a MiNDS.
  • Fig. S5. SEM images of the components of a BS tip aligner.
  • Fig. S6. SEM images of a completed MiNDS.
  • Fig. S7. The electrical characterization of S- and L-MiNDS at 37°C in saline.
  • Fig. S8. Chronic in vivo biocompatibility assessment.
  • Fig. S9. Pump characterization setup.
  • Fig. S10. Pump characterization protocol.
  • Fig. S11. Infusion profiles of the iPrecio pump.
  • Fig. S12. Large infusion characterization via PET.
  • Fig. S13. Small infusion characterization via PET.
  • Fig. S14. Infusion intensity and projection characterization via PET.
  • Fig. S15. PET imaging after pump implantation.
  • Fig. S16. Surgical procedure of an S-MiNDS with tungsten tetrode in vivo.
  • Fig. S17. Distinctive infusion effect on firing rate in a rat.
  • Fig. S18. Spectrograms from rat experiments.
  • Fig. S19. Surgical procedure of an S-MiNDS and two pumps implantation in vivo.
  • Fig. S20. Implanted pumps in a rat.
  • Fig. S21. High-performance liquid chromatography absorbance spectrum at various concentrations of muscimol.
  • Fig. S22. Behavioral study on rat models.
  • Fig. S23. Average waveforms during distinctive infusions in a NHP.
  • Fig. S24. Distinctive infusion effect on firing rate in a NHP.
  • Fig. S25. LFP power analysis of a NHP trial.
  • Fig. S26. Plot of dose/volume delivered in previous studies reported in the literature, injecting muscimol into the SN compared to MiNDS.
  • Table S1. Statistical analysis for muscimol inhibition of spike activity for two sessions in two rats and for two sessions in a NHP.
  • References (4953)

[Download PDF]