Supplementary Materials

Supplementary Material for:

Plasmacytoid dendritic cells promote systemic sclerosis with a key role for TLR8

Marie Dominique Ah Kioon, Claudio Tripodo, David Fernandez, Kyriakos A. Kirou, Robert F. Spiera, Mary K. Crow, Jessica K. Gordon, Franck J. Barrat*

*Corresponding author. Email: barratf{at}hss.edu

Published 10 January 2018, Sci. Transl. Med. 10, eaam8458 (2018)
DOI: 10.1126/scitranslmed.aam8458

This PDF file includes:

  • Materials and Methods
  • Fig. S1. BDCA4-positive cells express BDCA2, and both are specific markers for pDC.
  • Fig. S2. Monocytes of SSc do not express BDCA4.
  • Fig. S3. Reduction of the expression levels of TLRs in pDC-depleted PBMC.
  • Fig. S4. Monocytes are not depleted in pDC-depleted PBMC.
  • Fig. S5. CAL-101 specifically inhibits IFN-α but not IL-6 production by TLR9-activated pDCs.
  • Fig. S6. pDCs purified from HDs or SSc patients have similar expression of CXCR3B.
  • Fig. S7. Injection of DT leads to the specific depletion of pDCs in CLEC4C-DTR mice.
  • Table S1. Clinical and demographic characteristics of the 79 individual SSc patients as well as the overall description of the patient population are shown.
  • Table S2. Clinical and demographic characteristics of the six individual SLE patients as well as the overall description of the patient population are shown.

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Other Supplementary Material for this manuscript includes the following:

  • Table S3 (Microsoft Excel format). Primary data.