Supplementary Materials

Supplementary Material for:

Auditory-somatosensory bimodal stimulation desynchronizes brain circuitry to reduce tinnitus in guinea pigs and humans

Kendra L. Marks, David T. Martel, Calvin Wu, Gregory J. Basura, Larry E. Roberts, Kara C. Schvartz-Leyzac, Susan E. Shore*

*Corresponding author. Email: sushore{at}

Published 3 January 2018, Sci. Transl. Med. 10, eaal3175 (2018)
DOI: 10.1126/scitranslmed.aal3175

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Development of STDP in the fusiform cell circuit.
  • Fig. S2. The experimental timeline for the animal study.
  • Fig. S3. Noise exposure produces only temporary threshold and suprathreshold shifts.
  • Fig. S4. GPIAS behavioral assessment of tinnitus in guinea pigs.
  • Fig. S5. Human treatment groups had similar hearing thresholds.
  • Fig. S6. Reduction in tinnitus loudness in humans correlates with reductions in TFI.
  • Fig. S7. Tinnitus modulation maneuver checklist.
  • Table S1. Distribution of STDP learning rule type across unit/unit pairs in guinea pigs.
  • Table S2. Subject demographics.
  • Table S3. Correlations between changes in loudness and changes in TFI subscore.
  • References (5970)

[Download PDF]