Supplementary Materials

Supplementary Material for:

A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants

Katie J. Ryan, Charles C. White, Kruti Patel, Jishu Xu, Marta Olah, Joseph M. Replogle, Michael Frangieh, Maria Cimpean, Phoebe Winn, Allison McHenry, Belinda J. Kaskow, Gail Chan, Nicole Cuerdon, David A. Bennett, Justin D. Boyd, Jaime Imitola, Wassim Elyaman, Philip L. De Jager, Elizabeth M. Bradshaw*

*Corresponding author. Email: emb2280{at}

Published 20 December 2017, Sci. Transl. Med. 9, eaai7635 (2017)
DOI: 10.1126/scitranslmed.aai7635

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Higher expression of P2RY12 and TMEM119 in MDMi cells compared to monocytes.
  • Fig. S2. The proapoptotic gene BAX is increased in monocytes and MDM cells compared to MDMi cells.
  • Fig. S3. Many SNPs have differential eQTLs in MDMi cells compared to monocytes.
  • Legends for table S1 to S3
  • References (7277)

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Other Supplementary Material for this manuscript includes the following:

  • Table S1. (Microsoft Excel format). Differentially expressed genes in MDMi cells compared to bulk brain tissue.
  • Table S2. (Microsoft Excel format). Cis-eQTLs in MDMi cells.
  • Table S3. (Microsoft Excel format). LD-pruned list of cis-eQTLs in MDMi cells.

[Download Tables S1 to S3]