Supplementary Materials

Supplementary Material for:

Vaccination of dogs in an African city interrupts rabies transmission and reduces human exposure

Jakob Zinsstag,* Monique Lechenne, Mirjam Laager, Rolande Mindekem, Service Naïssengar, Assandi Oussiguéré, Kebkiba Bidjeh, Germain Rives, Julie Tessier, Seraphin Madjaninan, Mahamat Ouagal, Daugla D. Moto, Idriss O. Alfaroukh, Yvonne Muthiani, Abdallah Traoré, Jan Hattendorf, Anthony Lepelletier, Lauriane Kergoat, Hervé Bourhy, Laurent Dacheux, Tanja Stadler, Nakul Chitnis

*Corresponding author. Email: jakob.zinsstag{at}

Published 20 December 2017, Sci. Transl. Med. 9, eaaf6984 (2017)
DOI: 10.1126/scitranslmed.aaf6984

This PDF file includes:

  • Fig. S1. One-dimensional sensitivity analysis of simulation results on parameter values.
  • Fig. S2. One-dimensional sensitivity analysis of simulation results on parameter values with dog-to-dog transmission fixed as constant.
  • Fig. S3. Sensitivity analysis of the simulation results on the probability of detecting rabid dogs.
  • Fig. S4. Density of vaccinated dogs in N’Djaména in 2013 calculated on the basis of the data presented by Léchenne et al. (18).
  • Fig. S5. Schematic of mathematical model of rabies.
  • Fig. S6. Vaccination rates during the two campaigns in 2012 and 2013.
  • Fig. S7. Local and global sensitivity indices of the control reproductive number, Rc, to the model parameters.
  • Fig. S8. Sample simulation of the stochastic model, including the deterministic result.
  • Fig. S9. Results of the phylodynamic analysis showing median (red) and 95% HPD interval (black) for Re through time.
  • Table S1. State variables of dog rabies transmission model.
  • Table S2. Parameters of the rabies transmission model with estimated values and sources.
  • Legends for data files S1 and S2

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Other Supplementary Material for this manuscript includes the following:

  • Rabies Data1.txt. (incidence data)
  • Rabies Data2.txt. (genetic sequences of 33 dog rabies virus N-protein deposited in GenBank)

[Download Data Files S1 and S2]