Supplementary Materials

Supplementary Material for:

A degradation fragment of type X collagen is a real-time marker for bone growth velocity

Ryan F. Coghlan, Jon A. Oberdorf, Susan Sienko, Michael D. Aiona, Bruce A. Boston, Kara J. Connelly, Chelsea Bahney, Jeremie LaRouche, Sarah M. Almubarak, Daniel T. Coleman, Irute Girkontaite, Klaus von der Mark, Gregory P. Lunstrum, William A. Horton*

*Corresponding author. Email: wah{at}

Published 6 December 2017, Sci. Transl. Med. 9, eaan4669 (2017)
DOI: 10.1126/scitranslmed.aan4669

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Fully tryptic fragments generated in mass spectrometry analysis.
  • Fig. S2. Dissociation of mouse rNC1 into dimers and monomers.
  • Fig. S3. Lower limit of quantitation.
  • Fig. S4. CXM stability testing.
  • Fig. S5. Relationship of stadiometer-based height velocities to CXM.
  • Fig. S6. Relationship between serum, plasma, and DBS concentrations.
  • Fig. S7. Half-life of CXM.
  • Table S1. Technical characterization of CXM assay.
  • Table S2. Diurnal variation data.
  • Table S3. Blood sample data.

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