Supplementary Materials

Supplementary Material for:

Targeting STUB1–tissue factor axis normalizes hyperthrombotic uremic phenotype without increasing bleeding risk

Moshe Shashar, Mostafa E. Belghasem, Shinobu Matsuura, Joshua Walker, Sean Richards, Faisal Alousi, Keshab Rijal, Vijaya B. Kolachalama, Mercedes Balcells, Minami Odagi, Kazuo Nagasawa, Joel M. Henderson, Amitabh Gautam, Richard Rushmore, Jean Francis, Daniel Kirchhofer, Kumaran Kolandaivelu, David H. Sherr, Elazer R. Edelman, Katya Ravid, Vipul C. Chitalia*

*Corresponding author. Email: vichital{at}bu.edu

Published 22 November 2017, Sci. Transl. Med. 9, eaam8475 (2017)
DOI: 10.1126/scitranslmed.aam8475

This PDF file includes:

  • Materials and Methods
  • Fig. S1. An indolic solute–specific animal model.
  • Fig. S2. STUB1 regulation of TF protein.
  • Fig. S3. STUB1 interaction with TF.
  • Fig. S4. STUB1 expression in the YL-109–treated flow loops.
  • Fig. S5. AHR or STUB1 manipulation in uremic animal model.
  • Table S1. Demographic and clinical characteristics of patients included in the study to examine the vascular expression of STUB1 and TF.

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