Supplementary Materials

Supplementary Material for:

Lung cancer–associated pulmonary hypertension: Role of microenvironmental inflammation based on tumor cell–immune cell cross-talk

Soni Savai Pullamsetti, Baktybek Kojonazarov, Samantha Storn, Henning Gall, Ylia Salazar, Janine Wolf, Andreas Weigert, Nefertiti El-Nikhely, Hossein Ardeschir Ghofrani, Gabriele A. Krombach, Ludger Fink, Stefan Gattenlöhner, Ulf R. Rapp, Ralph Theo Schermuly, Friedrich Grimminger, Werner Seeger,* Rajkumar Savai*

*Corresponding author. Email: rajkumar.savai{at}mpi-bn.mpg.de (R.S.); werner.seeger{at}mpi-bn.mpg.de (W.S.)

Published 15 November 2017, Sci. Transl. Med. 9, eaai9048 (2017)
DOI: 10.1126/scitranslmed.aai9048

This PDF file includes:

  • Fig. S1. Dendritic cell recruitment in the pulmonary vasculature of human lung cancer tissues.
  • Fig. S2. Role of immune/inflammatory cells in lung cancer–associated vascular remodeling.
  • Fig. S3. Induction of pulmonary vascular cell proliferation by CM from cocultures of macrophages/T lymphocytes with lung cancer cells.
  • Fig. S4. Secreted factors in the CM of macrophage/SCC cocultures.
  • Fig. S5. Reduction of tumor growth by IKK2 down-regulation in epithelial cells.
  • Fig. S6. Proposed mechanism of PH development in lung cancer.
  • Table S1. Demographic data, tumor type, and tumor stage for samples undergoing histological examination.

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