Supplementary Materials

Supplementary Material for:

Engineering a highly elastic human protein–based sealant for surgical applications

Nasim Annabi,* Yi-Nan Zhang, Alexander Assmann, Ehsan Shirzaei Sani, George Cheng, Antonio D. Lassaletta, Andrea Vegh, Bijan Dehghani, Guillermo U. Ruiz-Esparza, Xichi Wang, Sidhu Gangadharan, Anthony S. Weiss, Ali Khademhosseini*

*Corresponding author. Email: n.annabi{at}neu.edu (N.A.); alik{at}bwh.harvard.edu (A.K.)

Published 4 October 2017, Sci. Transl. Med. 9, eaai7466 (2017)
DOI: 10.1126/scitranslmed.aai7466

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Effect of methacrylation on tropoelastin.
  • Fig. S2. Tensile test on MeTro hydrogel with different degrees of methacryloyl substitution.
  • Fig. S3. Tensile test for Progel.
  • Fig. S4. Compression test on MeTro hydrogel with different degress of methacryloyl substitution.
  • Fig. S5. In vitro two-dimensional studies on MeTro hydrogels.
  • Fig. S6. Images of in vivo tests on rat artery sealed by MeTro.
  • Fig. S7. Images of in vivo tests on rat lung sealed by MeTro.
  • Fig. S8. In vitro degradation of MeTro and MeTro-MMP hydrogels.
  • Fig. S9. Schematic of porcine lung leakage sealing using MeTro.
  • Table. S1. Comparison of surgical adhesives/sealants on the market.

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Other Supplementary Material for this manuscript includes the following:

  • Table S2. (Microsoft Excel format). Individual subject-level data.
  • Movie S1 (.mp4 format). Rat lung leakage sealing using MeTro.
  • Movie S2 (.wmv format). Ex vivo porcine lung leakage sealing using MeTro.