Supplementary Materials

Supplementary Material for:

Targeted inhibition of Gq signaling induces airway relaxation in mouse models of asthma

Michaela Matthey, Richard Roberts, Alexander Seidinger, Annika Simon, Ralf Schröder, Markus Kuschak, Suvi Annala, Gabriele M. König, Christa E. Müller, Ian P. Hall, Evi Kostenis, Bernd K. Fleischmann,* Daniela Wenzel*

*Corresponding author. Email: dwenzel{at}uni-bonn.de (D.W.); bernd.fleischmann{at}uni-bonn.de (B.K.F.)

Published 13 September 2017, Sci. Transl. Med. 9, eaag2288 (2017)
DOI: 10.1126/scitranslmed.aag2288

This PDF file includes:

  • Materials and Methods
  • Fig. S1. FR inhibits Gq protein signaling in Ca2+ imaging experiments in mTSMCs, and in DMR and bioimpedance measurements in hBSMCs.
  • Fig. S2. FR does not affect mouse heart rate when applied either locally or systemically.
  • Fig. S3. FR applied before OVA protects against airway hyperreactivity in mice.

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