Supplementary Materials

Supplementary Material for:

Increased adaptive immune responses and proper feedback regulation protect against clinical dengue

Etienne Simon-Lorière, Veasna Duong, Ahmed Tawfik, Sivlin Ung, Sowath Ly, Isabelle Casadémont, Matthieu Prot, Noémie Courtejoie, Kevin Bleakley, Philippe Buchy, Arnaud Tarantola, Philippe Dussart, Tineke Cantaert,* Anavaj Sakuntabhai*

*Corresponding author. Email: anavaj.sakuntabhai{at}pasteur.fr (A.S.); tcantaert{at}pasteur-kh.org (T.C.)

Published 30 August 2017, Sci. Transl. Med. 9, eaal5088 (2017)
DOI: 10.1126/scitranslmed.aal5088

This PDF file includes:

  • Fig. S1. Gating strategy identifying cell subsets.
  • Fig. S2. Viral load in asymptomatic and clinical dengue patients.
  • Fig. S3. Serum cytokines related to innate immune response and inflammation are not associated with the clinical outcome of DENV infection.
  • Fig. S4. Serum cytokines related to innate immune responses and inflammation are not associated with the clinical outcome of dengue infection in individuals undergoing secondary DENV infection.
  • Fig. S5. Asymptomatic viremic individuals undergoing secondary DENV infection show differentially regulated pathways and molecules related to antigen presentation.
  • Fig. S6. Increased T cell activation in asymptomatic viremic individuals undergoing secondary DENV infection.
  • Legends for tables S1 to S3

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Differentially expressed genes obtained by LIMMA.
  • Table S2 (Microsoft Excel format). GO enrichment analysis using GOrilla.
  • Table S3 (Microsoft Excel format). Ingenuity canonical pathways analysis of pathways significantly enriched in asymptomatic and clinical dengue infection.

[Download Tables S1 to S3]