Supplementary Materials

Supplementary Material for:

Targeting the vascular and perivascular niches as a regenerative therapy for lung and liver fibrosis

Zhongwei Cao,* Tinghong Ye, Yue Sun, Gaili Ji, Koji Shido, Yutian Chen, Lin Luo, Feifei Na, Xiaoyan Li, Zhen Huang, Jane L. Ko, Vivek Mittal, Lina Qiao, Chong Chen, Fernando J. Martinez, Shahin Rafii, Bi-Sen Ding*

*Corresponding author. Email: zhc2007{at} (Z.C.); bid2004{at}; dingbisen{at} (B.-S.D.)

Published 30 August 2017, Sci. Transl. Med. 9, eaai8710 (2017)
DOI: 10.1126/scitranslmed.aai8710

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Characterization of parenchymal cell incorporation in the mouse lungs and livers.
  • Fig. S2. EC-expressed HGF is required for bypassing fibrosis and stimulating regeneration after liver and lung injury.
  • Fig. S3. Expression of NOX4 in liver fibroblasts.
  • Fig. S4. Dual editing of vascular and perivascular niches promotes liver repair.
  • Fig. S5. EC-expressed HGF suppresses perivascular NOX4 expression to stimulate lung alveolar regeneration and attenuate fibrosis.
  • Fig. S6. Expression of NOX4 in lung fibroblasts.
  • Fig. S7. Dual editing of vascular and perivascular cells blocks fibrosis and facilitates lung repair.

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Individual subject-level data.

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